18 SEPTEMBER 2020
A NEW STUDY OF CARDIAC REPOLARIZATION IN AHC HAS BEEN LAUNCHED BY THE IAHCRC CONSORTIUM
A new study of cardiac repolarization in patients with AHC (QTc-AHC Study) has been launched by the Duke University team (A Landstrom, M Mikati, M Moya-Mendez, Duke University in North Carolina, USA).
They propose a quantitative study using electrocardiogram (ECG) data to further understand the impact of AHC genotype in relation to cardiac repolarization, specifically the resetting electrical activity of the heart after a heartbeat. A recently published study by Balestrini et al (2020) and previous work by Moya-Mendez et al (2020) describes differences in the electrical activity of the hearts of patients with different variations in the ATP1A3 gene. These electrical activity abnormalities can persist into adulthood and increase the likelihood of certain heart problems in the future.
The goal of this new project is to expand upon and validate these findings by including other institutions and increasing the power to detect an association between AHC genotype and cardiac phenotype.
The study is an IAHCRC multicenter study collecting ECG data, including medications and other relevant cardiac data, from all participating centers. .
(by Drs. Andrew Landstrom and Mary Moya-Mendez)